Samburu Serena Lodge is situated on the south banks of the Uaso Nyiro River, just outside the Buffalo Springs Reserve, in the lowlands beneath Mount Kenya. It is ideally placed for Safaris to the neighbouring Buffalo Springs and Shaba National Reserve. The lodge blend seamlessly with the neighbouring environment of soft green acacia woodlands and the river, whilst the architectural style uses local materials and traditional Samburu building motifs.

Samburu Serena Lodge boasts a wide choice of accommodation all facing the river, spread up and down the river in cottages, bandas and single or twin rooms. There are 62 rooms which have been built using exotic African woods. All guest rooms have private verandas with uninterrupted views of the languid river and the wildlife it attracts, as well as the countless crocodiles that make the waters their home.

The dining room is open on the riverside with long tables and large buffets, the Crocodile Bar overhangs the water and is a great view point for the nightly feeding of the crocodiles, the Pool Bar, with upper and lower terraces, offers also a wide range of selections.